Compulsive redosing - This component is highly pronounced in comparison to phenibut.Empathy, love, and sociability enhancement - Unlike alcohol which merely increases sociability through disinhibition, F-Phenibut presents entactogenic effects which, although much weaker than that of traditional entactogens such as MDMA, are still prominent and well-defined even at moderate doses.Early reports suggest that in comparison to other commonly used GABAgenic depressants such as alcohol or benzodiazepines, this compound produces less inebriation and more euphoria, giving it more recreational potential as well as a correspondingly higher risk of abuse.
In comparison to regular phenibut, this compound has a significantly faster onset, a shorter duration, and slightly less stimulation. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.
Phenibut pregabalin cross tolerance full#
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. As a result, they should be viewed with a healthy degree of skepticism. As the GABA system is the most prevalent inhibitory receptor set within the brain, its modulation may be responsible for the relaxing, sedating, and calming effects of F-Phenibut on the central nervous system.ĭisclaimer: The effects listed below cite the Subjective Effect Index ( SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. This, in turn, increases GABAergic activity. By binding to this site, F-Phenibut may reduce the release of several excitatory neurotransmitters, including glutamate, substance P, acetylcholine, and norepinephrine. It is also possible that F-Phenibut binds to the α2δ-1 site of voltage-gated calcium channels in a manner similar to that of other gabapentinoids. Additionally, the widely prescribed gabapentinoid pregabalin also possesses a similar structure as phenibut, except that the phenyl group is instead replaced with an isobutyl group in the S configuration.į-phenibut acts as a potent agonist of the GABA-B receptor and in this regard is more similar to baclofen than phenibut. It has an almost identical chemical structure to baclofen (only replacing a chlorine with a fluorine atom in the para-position of the phenyl group). It is a chiral molecule and thus has two potential configurations as (R)- and (S)-enantiomers. Īs with phenibut, F-Phenibut is a derivative of GABA, except with a fluorine-substituted phenyl group in the β-position of the molecule. It is a derivative of the naturally occurring inhibitory neurotransmitter γ-aminobutyric acid ( GABA), with an addition of a phenyl ring that allows it to cross the blood–brain barrier. The substance can be classified as a gabapentinoid, a class which contains other substances such as gabapentin, pregabalin, baclofen, and GABOB. It has recently become available through online research chemical vendors, although little is known about this substance, particularly its potential toxicity and addiction potential.
F-Phenibut possesses an effect profile similar to phenibut but with a faster onset, significantly increased potency, and shorter total duration. It is not a recommendation and should be verified with other sources for accuracy.į-Phenibut (also known as 4-Fluorophenibut, Fluorophenibut, Fluorobut, Baflofen and CGP-11130) is a central nervous system depressant and closely related structural analog of phenibut. See responsible use section.ĭISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. 5-amino-4-(4-fluorophenyl)-1-hydroxypentan-2-one
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